Combinatorial chemistry is the ability to simultaneously synthesize vast numbers of diverse compounds. Its techniques have revolutionized the drug discovery process, and are widely used throughout the biotechnology community. Aimed at a wide audience, this text is a down-to-earth introductionto small molecule combinatorial chemistry. It uses a tutorial approach to provide a detailed survey of solid-phase peptide synthesis and solution-phase synthesis. It also reviews current automated approaches and equipment for both solid- and solution-phase library synthesis.The dispersion effects of flow cells with detection volumes in the range 1a400 uD have been determined from peak width measurements of mixtures of dansylated amino acids separated on 250 X 4.6 mm i.d. analytical HPLC columns (49).
|Title||:||A Practical Guide to Combinatorial Chemistry|
|Author||:||Anthony W. Czarnik, Sheila Hobbs Dewitt|
|Publisher||:||Amer Chemical Society - 1997-01-01|