The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called qreactive neurogenesisq, yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes.... 2009; Ables et al., 2010; Aguirre et al., 2010; Chapouton et al., 2010; Ehm et al. , 2010; Imayoshi et al., 2010; Lugert et al., ... that the Ascl1::CreER locus can be used to lineage trace a subpopulation of neurogenic NSCs in vivo (Kim et al., 2011). ... Interestingly, genetic fate mapping of cells expressing individual Notchs revealed multiple lineages in bone marrow ... adult mammalian neurogenic niches show a remarkable capacity for self-repair and remodeling in response to lesionanbsp;...
|Title||:||Adult neurogenesis twenty years later: physiological function versus brain repair|
|Author||:||Paolo Peretto, Luca Bonfanti|
|Publisher||:||Frontiers Media SA - 2015-05-01|