For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for implementing preferred gas and liquid chromatographic methods, Advances in Chromatographic Techniques for Therapeutic Drug Monitoring is a comprehensive reference describing the theory and application of therapeutic drug monitoring in clinical laboratories. Edited by a distinguished authority in the field and containing contributions from a variety of experts, the book discusses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, issues related to pain management and herbal supplements, and therapeutic drug monitoring for a range of medications, including: Anticonvulsants Digitalis Cardioactive drugs Antidepressants Immunosuppressants Anti-cancer drugs Vancomycin and aminoglycosides Antibiotics Antiretroviral drugs Nonnarcotic analgesics Anti-inflammatory drugs Examing older and newer drugs, the book contains detailed discussions on the rationale for therapeutic drug monitoring of each class of drugs, along with their basic pharmacology and toxicology. An extensive list of references is provided at the end of each chapter so that those interested in implementing a new drug assay can find the most appropriate method for the intended drug.Although it is thought that a minimum analgesic drug level exists for most opioids [58a60], the minimum effective concentration ... Patients in pain management or addiction rehabilitation programs are typically monitored long-term to ascertain ... in vivo metabolic pathways and may therefore appear together when a precursor compound is administered [10, 24, 61]. ... Codeine is also converted to an inactive metabolite, norcodeine (10%), and to the active compounds hydrocodone (up to anbsp;...
|Title||:||Advances in Chromatographic Techniques for Therapeutic Drug Monitoring|
|Publisher||:||CRC Press - 2009-10-06|