Translational regulation is essential in cancer development and progression, as well as in response to therapeutic interventions. Alterations in translation factor levels, activity, and functional signaling to control the protein synthesis machinery may facilitate aberrant enhanced expression of proteins necessary for cellular transformation, promotion of angiogenesis, and inhibition of apoptosis in tumor cells.For example, one recent report has directly demonstrated the role of insulin growth factor signaling potentiating homologous recombination repair via IRS-1 regulation of Rad51 compartmentalization. Recruitment of activated IGF-IR by IRS-1 isanbsp;...
|Title||:||Alterations in Translational Control in Breast Cancer|
|Author||:||Steve E. Braunstein|
|Publisher||:||ProQuest - 2008|