An Atlas of Preimplantation Genetic Diagnosis

An Atlas of Preimplantation Genetic Diagnosis

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Extensively illustrated, this atlas is a manual for the establishment and realization of PGD within the framework of assisted reproduction and genetics services. Fully revised and updated, the atlas includes descriptions of the authors' pioneering work on polar body based PGD for genetic and chromosomal disorders. The authors' novel experience of PGD for late-onset disorders with genetic predisposition will be of special interest. Their accumulated PGD experience for poor-prognosis IVF patients presents further evidence of the improvement of clinical outcome and the requirement for meiotic error testing for a higher accuracy of preselecting aneuploidy-free embryos for transfer.The conditions of PCR analysis are different for each diagnostic system and require a preliminary work-up. ... Two hybridization TaqMan probes are designed for this purpose: one being a perfect match to the normal sequence and the other containing a mutant sequence. ... 6.14 and 6.15) The advantage of real-time PCR is that the PCR tubes do not need to be opened after the amplification reaction is anbsp;...

Title:An Atlas of Preimplantation Genetic Diagnosis
Author:Yury Verlinsky, Anver Kuliev
Publisher:CRC Press - 2004-12-22


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