Introduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development. Written by an experienced and talented author to complement his existing Introduction to Medicinal Chemistry, the book illustrates how organic synthesis makes important contributions throughout the drug design and discovery process - from the generation of novel drug structures to the improved efficiency of large scale synthesis. Avoiding excessively detailed descriptions of the underlying synthetic pathways, the book focuses on how synthesis can be used in a strategic way - how and why different synthetic approaches are adopted, and the pros and cons of each. With examples used extensively to illustrate the concepts presented, Introduction to Drug Synthesis is the ideal resource for any pharmaceutical or medicinal chemistry student who needs a thorough understanding of how the concepts of organic synthesis are applied to the development of therapeutic drugs. Online Resource Centre Introduction to Drug Synthesis is supported by an Online Resource Centre featuring: For registered adopters: - Figures from the book in electronic format; For students: - A suite of multiple-choice questions to support the learning process; - Additional case studies - More detailed descriptions of key synthetic reactions, as a source of further reference.Coupling reactions which involve the formation of an NaC bond are widely used in drug syntheses. The most common coupling reactions ... body as a metabolite of procainamide. It is not easy to react an amine directly with a carboxylic acid to anbsp;...
|Title||:||An Introduction to Drug Synthesis|
|Publisher||:||Oxford University Press, USA - 2015-01|