Antibiotics are truly miracle drugs. As a class, they are one of the only ones that actually cure disease as opposed to most drugs that only help relieve symptoms or control disease. Since bacteria that cause serious disease in humans are becoming more and more resistant to the antibiotics we have today, and because they will ultimately become resistant to any antibiotic that we use for treatment or for anything else, we need a steady supply of new antibiotics active against any resistant bacteria that arise. However, the antibiotics marketplace is no longer attractive for large pharmaceutical companies, the costs of development are skyrocketing because of ever more stringent requirements by the regulatory agencies, and finding new antibiotics active against resistant strains is getting harder and harder. These forces are all combining to deny us these miracle drugs when we need them the most. I provide a number of possible paths to shelter from this perfect storm.If we dona#39;t look at deaths, since very few patients die from pneumonia today ( because we have such good antibiotics in large part), but we rather look at time to normalization of temperature, we get a ... Clearly, antibiotics work and they work well. The overall mortality for pneumonia today, taking all comers in clinical trials, is around 3%. ... Do we need new antibiotics for community-acquired pneumonia?
|Author||:||David M. Shlaes|
|Publisher||:||Springer Science & Business Media - 2010-09-02|