Between 1935 and 1944, the field of microbiology, and by implication medicine as a whole, underwent dramatic advancement. The discovery of the extraordinary antibacterial properties of sulphonamides, penicillin, and streptomycin triggered a frantic hunt for more antimicrobial drugs that was to yield an abundant harvest in a very short space of time. By the early 1960s more than 50 antibacterial agents were available to the prescribing physician and, largely by aprocess of chemical modification of existing compounds, that number has more than tripled today. So used have we become to the ready availability of these relatively safe and highly effective 'miracle drugs' that it is now hard to grasp how they transformed the treatment ofinfection.This book provides the first comprehensive account of the development of antimicrobial agents of all kinds: antibacterial, antiviral, antifungal, antiprotozoal and anthelminthic compounds. It also offers a celebration of those involved with the agents that have surely led to the relief of more human and animal suffering than any other class of drugs in the history of medical endeavour.The notion that azole derivatives might have useful antifungal activity dates back to the work of Wayne Woolley at the ... Both clotrimazole and miconazole were on the market by 1973 and soon became popular, chiefly for the treatment of oralanbsp;...
|Publisher||:||Oxford University Press - 2008-02-21|