Although everybody had and will experience anxiety, its intensity, frequency and characteristics may vary from what can be considered as qnormalq to pathological. The development of benzodiazepine as anxiolytics has been a major step firstly in therapeutics and secondly in the understanding of the associated biological mechanisms. Recently, new drugs without secondary effects of benzodiazepines have been developed. The purpose of the book was to take stock of the present knowledge: clinical aspects of pathological anxiety, neurobiological mechanisms associated with stress and anxiety, molecular targets of potent anxiolytic drugs, new issues and directions.These results indicate that whereas scopolamine produced a deficit in working memory, chlordiazepoxide did not. Table 2. Effects of chlordiazepoxide and scopolamine on working memory performance of rats in an eight-arm radial maze .
|Title||:||Anxiety, Neurobiology, Clinic and Therapeutic Perspectives|
|Publisher||:||John Libbey Eurotext - 1993-01-01|