Applied Pharmacokinetics & Pharmacodynamics

Applied Pharmacokinetics & Pharmacodynamics

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The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy. This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.None of these methods consider the antimicrobial activity of combination antibiotics when they are present. ... The Hull-Sarubbi method uses an estimated stable creatinine clearance and a published dosing chart for each aminoglycoside to determine low, ... Others, such as the nomogram available in the Sanford guide, a€ vary the dose of gentamicin between 2.5 and 5.1 mg/kg depending on estimatedanbsp;...

Title:Applied Pharmacokinetics & Pharmacodynamics
Author:Michael E. Burton
Publisher:Lippincott Williams & Wilkins - 2006


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