Reviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin. Highlighting the historical evolution of the salicylates and the commercial development of aspirin, the book reviews the pharmacokinetics of the salicylates, ibuprofen, and paracetamol as a basis for understanding the biodisposition of these analgesic drugs. Leading specialists discuss the therapeutic role of aspirin in the prevention and treatment of thrombo-embolic diseases, its place along with non-acetylated salicylates in the treatment of rheumatic diseases and plain, and the potential applications for aspirin and related drugs as prophylactics for colon cancer, Alzheimer's disease, and vascular dementia. They also present comparisons with other drugs used to treat pain and inflammation. With extensive data and literature covering a broad field, this is the definitive reference on the actions and applications of aspirin, salicylates, and related drugs. Physicians, pharmacists, pharmacologists, toxicologists, and chemists will find this resource useful in their daily work. It will also be valuable to pharmaceutical companies and researchers in the development of newer agents and novel applications.Kim D. Rainsford ... of the effects of salicylates on the actions of transcription factors involved in their regulation (Chen et al., 1999; Perez et al., 2002). ... This type of pain is carried along thin myelinated A fibres at a velocity of 2.5 to 3.0m/s, giving fast transmission of the pain stimulus. ... This pain is transmitted by unmyelinated C fibres l Spinothalamic Figure 7.10 Diagram showing principal pain pathwaysanbsp;...
|Title||:||Aspirin and Related Drugs|
|Author||:||Kim D. Rainsford|
|Publisher||:||CRC Press - 2004-10-28|