Introduction There are two major classes of proteases that have been implicated in extracellular matrix (ECM) proteolysis: the plasminogen activator (PA) system and the zinc-ion-containing matrix metalloproteinases (MMPs) [1-3]. ... several other proteins of ECM that are degraded by plasmin, including gelatin, fibrinogen, type IV collagen, fibrinectin, lami- nin, elastin and proteoglycans [7-9]. ... A simplified diagram of the PA system involving the ECM degradation is shown in figure 1 .
|Title||:||Biological Signals and Receptors|
|Author||:||F. Fraschini, Daniel P. Cardinali, Russel J. Reiter, B. M. Stankov|