Underling biology that governs the age-dependent seizure susceptibility is a new, exciting research field for every pediatric epileptologists and developmental nouroscientists. From daily practice, clinicians are well aware about a close correlation between the degree of seizure susceptibility and age of the individual. Pathophysiological mechanisms involved are multiplex, including race/gender nutrition, receptors/ion channels, dysgenesis, pharmacokinetics of AEDs, acute illnesses/inflammation and many others. In this book, the top-ranked experts contributed their original papers dealing with the cutting edge of knowledge in various aspects of underlying biology. Each article presents a comprehensive review of the subjects, guiding the readers to better understanding the contemporary status of achievements in this challenging research field.epilepsy. While many different laboratory rat strains develop spontaneous absence seizures, espe- cially with age (Inoue et al., ... Around three months of age SWD begin to show up sporadically in the EEG of some WAG/Rij rats. ... Given that WAG/Rij rats are fully inbred, these observations do suggest that next to genetic- also environmental factors contribute to the expression of SWD in WAG/Rij rats.
|Title||:||Biology of seizures susceptibility in developement brain|
|Author||:||Takao Takahashi, Yukio Fukuyama|
|Publisher||:||John Libbey Eurotext - 2008-01-01|