Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography._ Deftly illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. It distills key concepts for understanding the practice and analysis of protein crystal structures and contains examples of biologically-relevant molecules, complexes, and drug target structures. Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.Crystallization is a special form of phase separation from a homogeneous solution, where the proteinrich phase in equilibrium with the protein solution is an ordered crystal. ... The pH ofa protein solution has a strong effect on the solubility, but crystallization does not preferentially occur at the isoelectric ... At this point, we have acquired a good working understanding of how to reduce protein solubility.
|Publisher||:||Garland Science - 2009-10-20|