Helps in understanding the complex interactions between host, tumor and cytotoxic or immunomodulatory agents. This work addresses the resistance of solid tumors to anticancer therapeutics by considering mechanisms that involve alterations in genetics and epigenetics, cellular biochemistry, and properties related to physiology of solid tumor mass.Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. ... Nat Rev Cancer 2004;4:296a307. 19. ... Inactivation of the DNA repair gene O6methylguanine-DNA methyltransferase by promoter hypermethylation is a common event inanbsp;...
|Title||:||Cancer Drug Resistance|
|Author||:||Beverly A. Teicher|
|Publisher||:||Springer Science & Business Media - 2007-11-09|