This much anticipated Third Edition provides a comprehensive presentation of the global burden and patterns of cancer occurrence, along with new developments in our understanding of cancer causation and prevention. Special attention is given to epidemiologic approaches that incorporate molecular biomarkers based on genomic and other emerging technologies, providing new insights into the role of genetic predisposition and gene-environment interactions in cancer induction. In addition, new chapters are included on social class disparities in cancer incidence and mortality, the role of obesity and physical inactivity in cancer etiology, the potential effects of electromagnetic fields and rediofrequency radiation, and the principles of cancer chemoprevention. The textbook is organized into five sections: Basic Concepts; The Magnitude of Cancer; The Causes of Cancer; Cancer by Tissue of Origin; Cancer Prevention and Control. In this new edition, Drs. David Schottenfeld and Joseph F. Fraumeni, Jr. have enlisted three distinguished Associate Editors: Drs. Jonathan Samet of Johns Hopkins University, Graham Colditz of Harvard University and Alice Whittemore of Stanford University.... refers to irreversible, chromosomal aberrations resulting in morphologically distinct cells (Gooderham and Carmichael, 2002). ... insensitivity to antigrowth signals; apoptotic escape; limitless replicative potential; sustained angiogenesis; and tissue ... Hereditary nonpolyposis colon cancer (HNPCC) is characterized by a DNA mismatch repair defect, which leads to an ... as 85% for breast cancer and 65% for ovarian cancer (Ford et al., 1998; Lakhani et al., 1998; Gayther et al., 2000).
|Title||:||Cancer Epidemiology and Prevention|
|Author||:||David Schottenfeld John G. Searle Professor of Epidemiology University of Michigan School of Public Health (Emeritus), Division of Cancer Epidemiology and Genetics National Cancer Institute Joseph F. Fraumeni Jr. Director|
|Publisher||:||Oxford University Press, USA - 2006-08-10|