The aim of this unique volume is to help medical researchers design clinical trials to improve survival, remission duration, or time to recurrence of disease. Written in a user-friendly step-by-step format, this work enables the researcher-with no background in statistics-to determine sample size and write statistical considerations for their protocols. It provides critical language which can help with FDA submissions and/or research grants. It also provides the mathematical justification of the material at a level consistent with one year of undergraduate mathematical statistics. It presents survival analysis methods at a more elementary level than any known text. Filled with tables, figures, plus an extensive appendix, this one-of-a-kind reference is an absolute must for all clinical researchers and biostatisticians.(Patients quitting the study or failing due to non-study related cause are alost to follow-upa.) The validity of a trial can be compromised by such losses, unless that are auninformative.a (Rubinstein et al. (1981) provide a formal method to adjust foranbsp;...
|Title||:||CRC Handbook of Sample Size Guidelines for Clinical Trials|
|Author||:||Jonathan J. Shuster|
|Publisher||:||CRC Press - 1990-09-25|