A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark qrelapseq or qdrug resistanceq phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.Proc Natl AcadSci USA 2001;98(11):6086a6091. 34. Marmorstein LY, Kinev AV, ChanGK, etal. A humanBRCA2 complexcontaining a structural DNA binding component influencescell cycle progression.Cell 2001;104(2):247a257. 35. Cortez Danbsp;...
|Title||:||DNA Repair in Cancer Therapy|
|Author||:||Lawrence C. Panasci, Moulay A. Alaoui-Jamali|
|Publisher||:||Springer Science & Business Media - 2004-03-19|