Drug Metabolism and Pharmacokinetics Quick Guide

Drug Metabolism and Pharmacokinetics Quick Guide

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Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.... RegulatoryInformation/Guidances/ucm079266. pdf. Accessed 28 June 2010 Frederick CB, Obach RS (2010) Metabolites in safety testing: a€œMISTa€ for the clinical pharmacologist. Clin Pharmacol Ther 87:345a€“350 Gan J, Ran Q, He B et alanbsp;...

Title:Drug Metabolism and Pharmacokinetics Quick Guide
Author:Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E.C.A. Hop
Publisher:Springer Science & Business Media - 2011-04-07


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