Dynamics and the Problem of Recognition in Biological Macromolecules

Dynamics and the Problem of Recognition in Biological Macromolecules

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From within complex structures of organisms and cells down to the molecular level, biological processes all involve movement. Muscular fibers slide on each other to activate the muscle, as polymerases do along nucleic acids for replicating and transcribing the genetic material. Cells move and organize themselves into organs by recognizing each other through macromolecular surface-specific interactions. These recognition processes involve the mu tual adaptation of structures that rely on their flexibility. All sorts of conformational changes occur in proteins involved in through-membrane signal transmission, showing another aspect of the flexibility of these macromolecules. The movement and flexibility are inscribed in the polymeric nature of essential biological macromolecules such as proteins and nucleic acids. For instance, the well-defined structures formed by the long protein chain are held together by weak noncovalent interac tions that design a complex potential well in which the protein floats, permanently fluctuating between several micro- or macroconformations in a wide range of frequencies and ampli tudes. The inherent mobility of biomolecular edifices may be crucial to the adaptation of their structures to particular functions. Progress in methods for investigating macromolecular structures and dynamics make this hypothesis not only attractive but more and more testable.Mahoney, W. C., Hermodson, M. A., Jones, B., Powers, D. D., Corfman, R. S. and Reek, J. R. (1984) J. Biol. ... 130, 2532-2536 Marion, D., Driscoll, P. C., Kay, L. E., Wingfield, P. T., Bax, Gronenborn, A. and Clore, G. M. (1989) ... 74, 557-564. Richardson, M. (1991) Methods Plant Biochem. 5, 259-305. Rydel, T. J., Ravichandran K. G., Tulinsky, A., Bode, W., Huber, ... Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harboranbsp;...

Title:Dynamics and the Problem of Recognition in Biological Macromolecules
Author:Oleg Jardetzky, Jean-François Lefèvre
Publisher:Springer Science & Business Media - 2012-12-06


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