Enantiomer Separation

Enantiomer Separation

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In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called a€œoptical resolutiona€ or simply a€œresolutiona€. Nowadays, the descriptions a€œenantiomer resolutiona€ or a€œenantiomer separationa€ are also commonly used. Accordingly, a€œEnantiomer Separationa€ is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.Chiral Crystallization of Achiral Materials Optically active molecules must crystallize into chiral space groups, but a racemic mixture ... In spite of impressive work on crystal engineering, predictions on a correlation between crystal symmetry andanbsp;...

Title:Enantiomer Separation
Author:Fumio Toda
Publisher:Springer Science & Business Media - 2007-11-04


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