These results develop a correlation between protein-DNA dynamics and biological function and begin to demystify how MutS is capable of performing so many different tasks in the cell.In an effort to gain additional insight into the correlation between DNA structure and MutS function, AFM studies were conducted ... Results revealed that two unique DNA conformations were induced by MutS at the mismatched base: bent and unbent (Wang, Yang et al. 2003). From these results, the DNA bending model for mismatch repair initiation was proposed (Figure 1.5 B). ... no evidence supporting a dynamic equilibrium between DNA bending and unbending induced by MutS.
|Title||:||Ensemble and Single-molecule Fluorescence Studies of DNA Mismatch Repair Initiation by MutS.|
|Author||:||Lauryn E. Sass|
|Publisher||:||ProQuest - 2007|