The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means aabovea genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, Gray JW, Leonhardt H, Jaenisch R (2003) Induction of ... Ruscetti S, Muegge K (2008) DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development . Epigenetics 3:134a142 Counts JL, Goodman JI (1994) Hypomethylation of DNA : an epigenetic mechanism involved in tumor promotion. ... Mutagenesis 22:247a 253 Lahtz C, Pfeifer GP (2011) Epigenetic changes of DNA repair genes in cancer.
|Title||:||Epigenetic Alterations in Oncogenesis|
|Author||:||Adam R. Karpf|
|Publisher||:||Springer Science & Business Media - 2012-09-06|