Difficult-to-treat severe asthma constitutes approximately 5-10% of the asthmatic population, and continues to present a considerable therapeutic challenge. Use of the pragmatic definitions over the past 10 years has led to an improved delineation of these patients. This monograph gathers expertise in the paediatric and adult severe asthma fields. Giving rise to a comprehensive edition that summarises what has been achieved in understanding the different phenotypes, their biomarkers and the reasons and mechanisms that underlie difficult-to-treat severe asthma as well as the refractoriness to i.The technique of sputum induction is not difficult, and sputum analysis is sensitive enough to reproducibly identify the different ... When performed by trained staff, and with monitoring of lung function, the technique is safe in patients with severeanbsp;...
|Title||:||European Respiratory Monograph 51: Difficult-To-Treat Severe Asthma|
|Author||:||K. Fan Chung, E.H. Bel, S.E. Wenzel|
|Publisher||:||European Respiratory Society - 2011-11|