Label-free detection techniques have an important role in many applications, such as situations where few molecules---rather than low molarity---need to be detected, such as in single-cell screening. While surface plasmon resonance (SPR) scattering from metal nanoparticles has been shown to achieve significantly higher sensitivity in gene arrays, such an approach has not been demonstrated for protein arrays. SPR-based sensors could either use simple absorption measurement in a UV-Vis spectrometer or possibly surface-enhanced Raman spectroscopy as the detection mechanism for molecules of interest.Hao, E. and G.C. Schatz, Electromagnetic fields around silver nanoparticles and dimers. Journal of Chemical Physics, ... Saj, W.M., FDTD simulations of 2D plasmon waveguide on silver nanorods in hexagonal lattice. Optics Express, 2005.
|Title||:||Fabrication and Characterization of a Plasmonic Biosensor Using Non-spherical Metal Nanoparticles|
|Publisher||:||ProQuest - 2007|