In Gene Regulatory Sequences and Human Disease, the Editor will introduce the different technological advances that led to this breakthrough. In addition, several examples will be provided of nucleotide variants in noncoding sequences that have been shown to be associated with various human diseases.This is of interest in light of the fact that NMP4 negatively regulates collagen transcription (Robling et al. ... 2005; Jin et al. 2009b). In accord with these results, the highest overall transcription has been observed with the a1997G/a1663delT/ +1245T haplotype (Jin et al. ... an important role in regulating bone cell function and maintenance of calcium homeostasis by binding to the vitamin D receptor ( VDR).
|Title||:||Gene Regulatory Sequences and Human Disease|
|Publisher||:||Springer Science & Business Media - 2012-05-30|