Different cancer types can result from a multiplicity of genetic and environmental factors. In recent years a number of genes have been identified as strong determinants for particular forms of cancer (particularly colon and breast cancer). The incomplete penetrance often evinced by the mutations of these genes has raised the possibility that additional endogenous or exogenous determinants contribute to cancer development or suppression. The major aim of this book is to present an integrated view of the various environmental, epidemiological and genetic determinants that contribute to a disease syndrome collectively known as qcancerq.... of Alfatoxin B1-induced mutations in a plasmid replicated in Xeroderma Pgimentosum and DNA repair proficient human cells. ... Somat Cell Mol Genet 14 :383-400 McGregor WG, Chen R-H, Lukash L, Maher VM, McCormick JJ (1991) Cellanbsp;...
|Title||:||Genes and Environment in Cancer|
|Author||:||Manfred Schwab, Hartmut M. Rabes, Klaus Munk, Peter H. Hofschneider|
|Publisher||:||Springer Science & Business Media - 2012-12-06|