Genetic Variation: A Laboratory Manualis the first compendium of protocols specifically geared towards genetic variation studies, and includes thorough discussions on their applications for human and model organism studies. Intended for graduate students and professional scientists in clinical and research settings, it covers the complete spectrum of genetic variationafrom SNPs and microsatellites to more complex DNA alterations, including copy number variation. Written and edited by leading scientists in the field, the early sections of the manual are devoted to study design and generating genotype data, the use of resources such as HapMap and dbSNP, as well as experimental, statistical, and bioinformatic approaches for analyzing the data. The final sections include descriptions of genetic variation in model organisms and discussions of recent insights into human genetic ancestry, forensics, and human variation.Linkage Disequilibrium and Marker Allele Frequency Power to detect association is greatest when linkage ... GENOME-WIDE ASSOCIATION Recent advances in high-throughput technology and decreased genotyping costs (Matsuzaki et al.
|Author||:||Michael P. Weiner|
|Publisher||:||CSHL Press - 2007|