Genetics of Complex Disease

Genetics of Complex Disease

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Genetics of Complex Disease examines how the identification of genetic variations that increase or reduce the risk of common, genetically complex, diseases can be used to improve our understanding of the pathology of many common diseases; enable better patient management and care; and help with differential diagnosis. It starts with the questions of qwhatq, qwhyq and qhow, q and continues with more specific topics such as HLA and immunogenetics, pharmacogenetics, cancer, and diabetes. It finishes with a discussion of ethical issues, and looks to future developments. Genetics of Complex Disease is designed for advanced undergraduate and graduate students in the biomedical sciences and medicine.HLA-DQB1*02 HLA-A1 HLA-DRB1*03 C4A*Q0 HLA-B8 HLA-C7 Figure 1.5: Extreme linkage disequilibrium. the mHc illustrates extreme linkage ... If the population is large enough, allele frequencies remain stable and do not change significantly as a result of random reproduction, and ... The lower-left quadrant of Table 1.1 shows evolutionary forces that decrease genetic variation within populations.

Title:Genetics of Complex Disease
Author:Peter Donaldson, Ann Daly, Luca Ermini, Debra Bevitt
Publisher:Garland Science - 2015-07-30


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