We also evaluated the association between DNA repair variants, cigarette smoking, and baseline mean IMT using linear regression models in ARIC participants selected into the CRS. When priors for genetic and environmental effects were added to the first-stage linear regression model, tagSNPs rs3213282 ( XRCC1), rs3213245 (XRCC1), rs3212024 (XRCC3 ), and rs3136814 (APEX1) were associated with increases in the estimated effect of ever-smoking on baseline mean IMT while tagSNPs rs3136817 (APEX1) and rs1799794 (XRCC3) were associated with decreases.Nucleotide excision repair (NER) NER operates primarily on bulky helix- distorting DNA lesions such as pyrimidine dimers, ... exhibit extreme sensitivity to UV radiation and a substantially (1000-fold) increased risk of skin cancers351 and (agt;10-fold) internal tumors352. ... The NER pathway repairs DNA strand damage in a a#39;cut-and-pastea#39; manner involving five stages (Figure 6): 1) recognition of DNAanbsp;...
|Title||:||Genotype-by-smoking Interaction and the Risk of Atherosclerosis and Its Clinical Sequelae|
|Author||:||Christy L. Avery|
|Publisher||:||ProQuest - 2007|