Glycinergic transmission: physiological, developmental and pathological implications

Glycinergic transmission: physiological, developmental and pathological implications

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Inhibitory glycine receptors (GlyRs) containing the alpha1 and beta subunits are well known for their involvement in an inherited motor disorder (hyperekplexia) characterised by neonatal hypertonia and an exaggerated startle reflex. However, it has recently emerged that other GlyR subtypes (e.g. those containing the alpha2, alpha3 and alpha4 subunits) may play more diverse biological roles. New animal models of glycinergic dysfunction have been reported in zebrafish (bandoneon, shocked), mice (cincinatti, Nmf11) and cows (CMD2). In addition, key studies on neurotransmitter transporters for glycine (GlyT1, GlyT2, VIAAT) have also revealed key roles for these presynaptic and glial proteins in health and disease. Molecular modelling and structure/function studies have also provided key insights into allosteric signal transduction mechanisms and the diverse pharmacology of glycine receptors. This Research Topic aims to bring together experts in the field of glycinergic transmission, and invite research articles or topical reviews to provide an up-to-date perspective on the insights into receptor, transporter and synaptic function that can be gained by the study of glycinergic transmission.... optic stimulation to the maturation of retinal ganglion cell connectivity is mediated via GlyRsynaptic transmission. ... differentiationa¬Ä¬Ě genes such as GlyT2 or VIAAT is a particularly interesting problem given that many genes associated with the ... a hypothesis supported by co-expression data (Aubrey et al., 2007) and electophysiological data (Muller et al., 2006, 2008). ... 2010 | Volume 3 | Article 11 | 39 Chalphin and Saha Glycinergic transmission in development.

Title:Glycinergic transmission: physiological, developmental and pathological implications
Author:Robert J. Harvey, Jean-Michel Rigo
Publisher:Frontiers E-books -


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