This Handbook brings together and integrates comprehensively the core approaches to fear and anxiety. Its four sections: Animal models; neural systems; pharmacology; and clinical approaches, provide a range of perspectives that interact to produce new light on these important and sometimes dysfunctional emotions. Fear and anxiety are analyzed as patterns that have evolved on the basis of their adaptive functioning in response to threat. These patterns are stringently selected, providing a close fit with environmental situations and events; they are highly conservative across mammalian species, producing important similarities, along with some systematic differences, in their human expression in comparison to that of nonhuman mammals. These patterns are described, with attention to both adaptive and maladaptive components, and related to new understanding of neuroanatomic, neurotransmitter, and genetic mechanisms. Although chapters in the volume acknowledge important differences in views of fear and anxiety stemming from animal vs. human research, the emphasis of the volume is on a search for an integrated view that will facilitate the use of animal models of anxiety to predict drug response in people; on new technologies that will enable direct evaluation of biological mechanisms in anxiety disorders; and on strengthening the analysis of anxiety disorders as biological phenomena. ac Integrates animal and human research on fear and anxiety ac Presents emerging and developing fields of human anxiety research including imaging of anxiety disorders, the genetics of anxiety, the pharmacology of anxiolysis, recent developments in classification of anxiety disorders, linking these to animal work ac Covers basic research on innate and conditioned responses to threat ac Presents work from the major laboratories, on fear learning and extinction ac Reviews research on an array of neurotransmitter and neuromodulator systems related to fear and anxiety ac Compares models, and neural systems for learned versus unlearned responses to threat ac Relates the findings to the study, diagnostics, and treatment of anxiety disorders, the major source of mental illness in modern society (26 % of Americans are affected by anxiety disorders!)When a more ethological approach is applied, it reveals a profile of high reactivity and escape motivation for wild ... Laboratory Swiss-Webster mice tested in a MDTB show the full range of defensive behaviors, albeit exhibiting lower levels of both flight and freezing when compared to ... Augustsson, H. and Meyerson, B.J. ( 2004) Exploration and risk assessment: a comparative study of male house mice anbsp;...
|Title||:||Handbook of Anxiety and Fear|
|Author||:||D. Caroline Blanchard, Guy Griebel, David J Nutt|
|Publisher||:||Elsevier - 2011-09-02|