This is the first comprehensive reference work on toxicologic pathology, an emerging field that integrates the mechanisms of toxic injury with the resulting pathology. Chapters deal systematically with organ-specific toxic injury, describing the mechanisms of injury, morphological expression of the injury, and evaluation of the pathology. Additional chapters introduce the field to the uninitiated and address such topics as techniques used for morphological evaluation, risk assessment, and regulatory aspects. The Handbook of Toxicologic Pathology will quickly establish itself as the classic reference work in this field for years to come. Key Features * Comprehensive, quser friendlyq reference text on toxicologic pathology * Large, easy-to-use 8 1/2q x 11q, double-column format * Systematic approach to each organ or system * More than 500 illustrations and 90 tables complement the text * Over 2, 000 references for easy access to the primary literature * Unique chapters written by leading authoritiesSimilarly, the cytochrome-P-450-dependent deethylation of ethoxycoumarin does not yield an electrophilic intermediate, but ... The stepwise reduction of oxygen to water produces a variety of potentially toxic intermediates. ... In turn, a second electron reduces superoxide to the peroxide ion. At physiological pH, the peroxide ion exists primarily as hydrogen peroxide. ... However, when the generation of such species overwhelms the cella#39;s ability to detoxify them, cell injury can result.
|Title||:||Handbook of Toxicologic Pathology|
|Author||:||Wanda M. Haschek, Colin G. Rousseaux|
|Publisher||:||Elsevier - 2013-10-22|