Health-related Fitness, Physical Activity, and Non-alcoholic Fatty Liver Disease

Health-related Fitness, Physical Activity, and Non-alcoholic Fatty Liver Disease

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Nonalcoholic fatty liver disease (NAFLD) has been referred to as the hepatic manifestation of the metabolic syndrome (MS). There is a lower prevalence of MS in individuals with higher health-related fitness (HRF) and physical activity (PA) participation. The relationship between NAFLD severity and HRF and PA is unknown. The purpose of this study was to document and compare measures of HRF and PA in patients with a histological spectrum of NAFLD. Thirty-seven patients with liver biopsy confirmed-NAFLD (18F/19M; age = 45.9 +/- 12.7 yr) completed assessment of cardiorespiratory fitness (CRF, VO2peak), muscle strength (quadriceps peak torque), and body composition (%fat). Current and historical PA was also assessed. Liver histology classified NAFLD severity by steatosis (mild, moderate, severe), fibrosis stage (stage 1 vs. stage 2/3), necroinflammatory activity (NAFLD Activity Score; a‰c 4, NAS1 vs. a‰y 5, NAS2) and diagnosis of nonalcoholic steatohepatitis by Brunt criteria (NASH vs. NotNASH). ANOVA and independent t-tests were used to determine the differences among the various groups. Less than 20% of the patients met recommended guidelines for PA and 97.3% were classified as increased risk of morbidity and mortality by %fat. No differences were detected in VO2peak (x=26.8 +/- 7.4 ml/kg/min) or %fat (x=38.6 +/- 8.2%) among the steatosis or fibrosis groups. Peak VO2 was higher in the NAS1 vs. NAS2 (p=0.013) and notNASH vs. the NASH (p= 0.048). Patients with NAFLD of differing severity have sub-optimal HRF. CRF was significantly worse in those with NASH and greater NAS. Lifestyle interventions to improve HRF may be beneficial in reducing the associated risk factors and preventing progression of NAFLD.HDL primarily functions to move cholesterol from the peripheral tissues to the liver for excretion (reverse cholesterol transport). The biggest player in TG transport is the chylomicron, as it carries and delivers the largest quantity of TG.

Title:Health-related Fitness, Physical Activity, and Non-alcoholic Fatty Liver Disease
Author:Joanne B. Krasnoff
Publisher:ProQuest - 2007


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