Histone Deacetylases Control Skeletal Muscle Remodeling

Histone Deacetylases Control Skeletal Muscle Remodeling

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Skeletal muscle is a highly adaptive tissue capable of physiological remodeling in response to functional demands imposed on the muscle. Motor neurons innervate skeletal muscle and communicate via neural activity, an electrical form of signaling critical for dictating muscle size, muscle fiber-type composition, and muscle metabolism, all of which are required for proper skeletal muscle homeostasis. During pathological conditions including muscular dystrophies, muscle atrophy disorders, and neuromuscular disease for example, muscle homeostasis is altered leading to often devastating clinical consequences. We have analyzed the molecular signaling pathways in both physiological and pathological contexts that facilitate muscle remodeling to alter muscle properties in response to changing environmental demands.In most models of muscle atrophy, atrophic muscles display a slow-to-fast transition that correlates with a reduction in the ... Activity-dependent transcriptional remodeling Muscle can undergo remodeling to meet changing functional demands.

Title:Histone Deacetylases Control Skeletal Muscle Remodeling
Author:Todd J. Cohen
Publisher:ProQuest - 2007


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