The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings. NEW TO THE FOURTH EDITION: *This edition is in full color and features nearly 200 high-quality images *Provides extended commentary on the relevance of pathological findings and features a fully updated bibliography containing sources for further reading *Includes new content coverage on the commonly used transgenic animal models that are used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions.... and their messenger RNAs increase in muscle fibers when protein degradation is maximal.329 Although drugs and other ... produce muscle atrophy in association with degeneration, necrosis and inflammation, simple muscle atrophy can beanbsp;...
|Title||:||Histopathology of Preclinical Toxicity Studies|
|Publisher||:||Academic Press - 2011-11-08|