In support of our hypothesis, these data demonstrated that combination treatment with EN+GLP-2 induce a synergistic growth response in parenterally-fed rats with or without SBS. Moreover, our data support that IGF-I is one of the downstream mediators of GLP-2 action in a physiological model of intestinal growth.Resection was the only treatment to induce growth of the residual colon. ... However, individual treatment with GLP-2 did not significantly alter sucrase specific activity compared with TPN alone. ... almost 4-fold) of proglucagon mRNA in colon than that seen with transection control surgery (main effect of surgery, P alt; 0.0001)anbsp;...
|Title||:||Interaction Between Enteral Nutrients and Glucagon Like Peptide-2 in Intestinal Adaptation in Parenterally-fed Rats|
|Publisher||:||ProQuest - 2008|