Introduction. With the increasing number of institutionalized elderly individuals in the United States projected to increase over the next thirty years, nutritional deficiencies associated with polypharmacy are a growing concern. Proton pump inhibitors (PPI), which were originally intended for short-term use to heal esophageal erosions, are among the most commonly prescribed medications in the United States, and are often prescribed for long term use without adequate follow-up by a physician. PPI have been shown to decrease absorption of food-bound vitamin B12, and to cause a decrease in vitamin B12 status in elderly individuals. Purpose. The purpose of this study was to determine whether institutionalized elderly individuals on long term (g12 months) PPI therapy were more likely to have vitamin B12 deficiency than individuals who were not taking, and had not taken PPI for at least 30 days. We also sought to show that Nascobal vitamin B12 nasal spray would improve the B12 status of institutionalized elderly individuals on long term PPI therapy after eight weeks of treatment. Subjects and methods . Subjects were long term care (LTC) residents between the ages of 60 and 89 years with no history of pernicious or megaloblastic anemia, so use of vitamin B12 supplements, and serum creatinine (Cr)Articles are copyedited according to AJCN style policy, the aUniform Requirements for Manuscripts Submitted to Biomedical Journals, a and the style manual of the Council of Science Editors (Scientific style and format: the CSE manual foranbsp;...
|Title||:||Is There a Relationship Between Long Term Use of Proton Pump Inhibitors and Vitamin B12 Deficiency in Institutionalized Elderly Individuals?|
|Author||:||Nancy R. Rozgony|
|Publisher||:||ProQuest - 2008|