Epithelial cells cover the outer and inner surfaces of the body, forming a selective polarized barrier between the intercellualar space and the 'external' world. Linking the cells of this continuous layer and contributing to epithelial organization and function are specialized membrane domains--desmosomes, gap junctions, and occluding junctions. The contributors to this multidisciplinary symposium volume explore the nature of such junctional structures, focusing on the molecular organization and diversity of their constituent proteins, their formation and control, and interactions with ions and cytoskeletal elements. The physiological significance of cell-cell interaction in epithelia is considered, with reference to cell adhesion, barrier formation and intercellular communication, and to the functional implications for tissue architecture, embryonic development, morphogenesis and carcinogenesis.Cell populations can form into multiple compartments which can interact with each other either by reduced trans-boundary junctional communication or by extracellular signals. ... In contrast to the situation in culture, the a#39;wiring diagramsa#39; of cell coupling in vivo are ordered. ... near the edges of liver from weanling rats, although the extent is much reduced after partial hepatectomy (Meyer et al 1981).
|Title||:||Junctional Complexes of Epithelial Cells|
|Author||:||CIBA Foundation Symposium|
|Publisher||:||John Wiley & Sons - 2008-04-30|