This volume provides an overview of the latency strategies developed during the estimated 200, 000 year-long coevolution of Alpha-, Beta- and Gammaherpesvirinae and their host species. While the main emphasis is on herpesviruses infecting humans, relevant cases if herpesviruses infecting animals are covered as well. Special emphasis is given to results on molecular mechanisms regulating latent promoters of herpesvirus genomes and signals and molecular pathways resulting in reactivation of latent viral genomes.The function of the MuHV LANA homo- logue in the replication and maintenance of the latent viral genome might be similar to that of the EBNA1 protein (Ambinder et al., 1991; Rajcani and KAodelova, 2003). ... latent (nonproductive) infection had been established (between days 21 to 70 p.i.), revealed the presence of mRNA transcripts corresponding with the MHV-specific M3 gene (Simas et al., 1999).
|Title||:||Latency Strategies of Herpesviruses|
|Author||:||Janos Minarovits, Eva Gonczol, Tibor Valyi-Nagy|
|Publisher||:||Springer Science & Business Media - 2006-12-13|