Restenosis remains the Achilles heel of Percutaneous Coronary Interventions. Numerous pharmacological agents have been tested in order to reduce acute thrombosis and the hyperproliferative cellular response, and drug eluting stents-using the stent as a platform for local drug delivery-are now considered a significant breakthrough in interventional cardiology. Pioneers in the field, the editors of Local Drug Delivery for Coronary Artery Disease have assembled an excellent team of contributors who offer their experience with threatened vessel closure and restenosis, acute thrombosis, hyperproliferative cellular response, stents and local drug delivery. They share their expertise on all aspects of the field, including a discussion of results from preclinical and clinical studies, and they examine alternative methods of molecular delivery to the vessel wall. With coverage of the most current methods and applications, as well as a host of photographs illustrating their implementation, this book will serve as an excellent reference for cardiologists, pharmacologists, cardiac surgeons, and trainees.eluting. stents: a. potential. therapy. in. the. prevention. of. restenosis. Gishel New , Nicholas Kipshidze, Alexander S Abizaid, and Antonio Colombo ... Our preliminary work using local delivery of estrogen via a drug eluting stent to prevent restenosis looks encouraging. ... The cardioprotective effects of estrogen have been know for many years. ... effect in clinical trials to date, a large volume of in vitro and in vivo data suggest that estrogen can retard atherosclerosis and inhibit restenosis.
|Title||:||Local Drug Delivery for Coronary Artery Disease|
|Author||:||Edoardo Camenzind, Ivan De Scheerder|
|Publisher||:||CRC Press - 2005-06-14|