Mdm2 is a key member of the p53 tumor suppressor pathway, as it negatively regulates p53 stability and activity. Mdm2 is amplified in 10% of all human cancers, and studies have shown that overexpression of the Mdm2 protein promotes transformation. The majority of Mdm2 research has focused on its function in the p53 pathway; however, Mdm2 also has less characterized p53-independent functions that contribute to transformation when deregulated.mM sodium fluoride, 10 mM (3-glycerophosphate, and 0.1 mM Na3V04. Protein was measured as described above. Following separation by SDS-PAGE and transfer to nitrocellulose (Protran, Schleicher aamp; Schuell) or PVDF (Bio-Rad), proteinsanbsp;...
|Title||:||Mdm2 Inhibits DNA Double-strand Break Repair and Promotes Transformation Through Interaction with Nbs1|
|Publisher||:||ProQuest - 2008|