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Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. The synthesis and release of melatonin are stimulated by darkness and suppressed by light, suggesting the involvement of melatonin in circadian rhythm and regulation of diverse body functions. Levels of melatonin start to increase prior to bedtime. Synthetic melatonin supplements have been used for a variety of medical conditions, most notably for disorders related to sleep. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This book presents a full spectrum of research on melatonin and is destined to become an essential reference for anyone interested in melatonin.Daily MT rhythm of reptiles (turtle, Vivien-Roels and Arendt 1983, lizard, Underwood and Harless 1985) can be altered by changes in ... At the same time, environmental factors can modify the phase, the actual state of the biological clocks when affecting them repeatedly. ... These findings have substantially altered our understanding on the biological control mechanisms and profoundly influenced ouranbsp;...

Author:S. R. Pandi-Perumal, Daniel P. Cardinali
Publisher:Nova Publishers - 2007


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