This book highlights the importance of phytochemicals and mitochondria in cancer prevention and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phytochemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer progression. Mitochondria, organelles within a cell, are a critical target for phytochemicals in regulating the initiation, promotion, and progression of cancer. The book is divided into three parts to better communicate the important findings related to phytochemicals and mitochondria in cancer research. The first part describes updates on environmental and genetic factors causing cancer initiation and progression, the role of mitochondria function in regulating the process of tumorigenesis, and the role of mitochondria in regulating cell death such as apoptosis, autophagy, and necroptosis. The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phytochemicals in cancer prevention, updates on basic research related to phytochemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phytochemicals. The third part provides updates on phytochemicals targeting mitochondria for cancer therapy, an overview of action of phytochemicals on cancer stem cells, updates on the role of microRNA in phytochemicals-based therapy of cancer, and updates on phytochemicals-based translation research on therapy for metastatic cancer.... and Departamento de Sanidad 2011111141), DiputaciA³n Foral de Gipuzkoa OF 53/2011 and Instituto de Salud Carlos III AcciA³n EstratAcgica en Salud PI2010- 01035. ... Tissue repair and stem cell renewal in carcinogenesis. ... Zhang X, He X, Pavlick A, Gutierrez MC, Renshaw L, Larionov AA, Faratian D, Hilsenbeck SG, Perou CM, Lewis MT, Rosen JM, ... Proc Natl Acad Sci U S A 106:13820a13825 Das A, Banik NL, Ray SK (2010) Flavonoids activated caspases for apoptosis inanbsp;...
|Title||:||Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy|
|Publisher||:||Springer Science & Business Media - 2013-12-11|