?Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. ?So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.2007). The Xlsirts family of repeat-containing lncRNAs and the bifunctional VegT mRNA are required for the integrity of the oocyte ... However, regulation by small ncRNAs, including piRNAs and endo-siRNAs, is essential for germline specification and maintenance from worm to human (see ... A recently described X-linked lncRNA, Tsx, appears to have specific functions in the germline ( Anguera et al.
|Title||:||Molecular Biology of Long Non-coding RNAs|
|Author||:||Ahmad Khalil, Jeff Coller|
|Publisher||:||Springer Science & Business Media - 2013-09-20|