Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.to alkenes by dehydrogenation reactions in which hydrogen atoms are removed. Benzene being unsaturated is expected to be very reactive but, actually it is quite unreactive. ... When the aromatic ring already contains a substitu- ent, its reactivity will be greater or less than that of benzene itself. ... easier since the hydroxyl (aOH) group already present on the benzene ring activates the electrophilic attack of iodine ortho (o), meta (m), or para (p), depending on their relative position.
|Publisher||:||Springer Science & Business Media - 2009-07-13|