The data indicate multiple mechanisms of morphine hyperalgesia, with utilization being at least partly dependent upon female sex hormones. Some of the conclusions arising from these findings are outside of current conceptualizations, yielding new insights into the clinical utility and physiological circuitry underlying morphine analgesic therapy.drug that can prevent morphine glucoronidation (Faura, Olaso, Garcia, aamp; Horga, 1996), might begin to elucidate the contribution of M3G ... Unremitting hyperalgesia was only demonstrated in our study following low-dose infusion which had no analgesic or ... Patients receiving long-term opioid agonist therapies (OAT) for addiction, such as methadone or buprenorphine ... persistent hyperalgesia even after cessation of opioid use (Pud et al., 2005), but also did not report sex differences.
|Title||:||Morphine Hyperalgesia: Contribution of Opioid Receptors, Dosing Regimen, and Gonadal Hormones|
|Author||:||Aaron N. Juni|
|Publisher||:||ProQuest - 2008|