The use of animal models is a key aspect of scientific research in numerous fields of medicine. Movement Disorders, Second Edition vigorously examines the important contributions and application of animal models to the understanding of human movement disorders, and serves as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an ancillary website with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson's disease, Huntington's disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration, and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders. Introduces the scientific foundations for modern movement disorders research Contributing authors are internationally known experts Completely revised with 20% new material Provides a comprehensive discussion of genetics for each type of movement disorder Covers Parkinson's disease, Huntington's disease, dystonia, tremors, and tics Supported by a video library of movement disorders in patients with associated animal models hosted on a companion website(A) Schematic diagram of the pole test apparatus, which is a 50cm long wooden pole stabilized on a base. (B) A picture of a ... This effect was also reported in the R6/2 genetic HD mouse model (Cummings et al., 2012). The pole test is aanbsp;...
|Author||:||Mark S. LeDoux|
|Publisher||:||Elsevier - 2014-10-24|