Our work represents the first in-depth study of novel lineage-specific genes expressed in cattle placenta---their identification, bioinformatic characterization, inferred functions, and phylogenetic profiling. Starting from a cattle placenta cDNA library, a combination of bioinformatics, comparative genomics and transcript profiling was used to identify and characterize 91 novel lineage-specific transcripts (LSTs). Of these 91, 21 are candidate non-coding RNAs, and the rest are coding genes. Approximately half the genes showed tissue-preference in their expression. The genes encoding the LSTs were found to be significantly associated with subtelomeric regions, which are hotspots for segmental duplications and genes that are co-opted for new functions.... at least 13 out of 17 other tissues : R (0/R (any other tissue) agt; 2, where R is the normalized intensity ratio (tissue:reference). 2.5.3 Analysis of the cattle and assumptive human genome context of NTs The number of NTs with matches in the ... Using the cattle-human comparative map [Everts-van der Wind et al, 2005] also available on the UCSC Human Genome Browser, the position of the NTs on cattleanbsp;...
|Title||:||Novel Lineage Specific Genes Expressed in Cattle Placenta: Discovery, Functional Annotation and Evolution|
|Author||:||Charu Gupta Kumar|
|Publisher||:||ProQuest - 2008|