This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...asynchronous development are through effects of chemicals on peripheral thyroid hormone action and/or thyroid hormone metabolism in developing tissues such as is observed with deiodinase inhibitors. 53. The evaluation of test animals foranbsp;...
|Title||:||OECD Guidelines for the Testing of Chemicals, Section 2: Effects on Biotic Systems Test No. 231: Amphibian Metamorphosis Assay|
|Publisher||:||OECD Publishing - 2009-09-08|